Sample interview questions: Can you discuss your knowledge of different statistical methods used in clinical pharmacology research?
Sample answer:
1. Descriptive Statistics:
- Central Tendency Measures: Mean, Median, and Mode provide an overview of the typical value in a dataset.
- Variability Measures: Standard Deviation, Variance, and Range quantify the spread of data.
- Graphical Representations: Box plots, scatterplots, and histograms visually summarize data distribution.
2. Inferential Statistics:
- Hypothesis Testing: Used to determine if there is a statistically significant difference between two or more groups. Common tests include t-test, ANOVA, and chi-square test.
- Confidence Intervals: Provide a range of values within which the true population parameter is likely to fall with a specified level of confidence.
- Regression Analysis: Examines the relationship between variables and enables predictions based on a mathematical model. Includes linear regression, logistic regression, and nonlinear regression.
3. Pharmacokinetic and Pharmacodynamic Analysis:
- Pharmacokinetic Modeling: Describes the absorption, distribution, metabolism, and excretion of drugs in the body over time. Models include compartmental models, non-compartmental models, and physiologically-based pharmacokinetic models.
- Pharmacodynamic Modeling: Investigates the relationship between drug concentration and its effect on the body. Models include Emax models, sigmoidal models, and Hill models.
4. Meta-Analysis:
- Systematic Review: Aggregates results from multiple studies to provide a comprehensive overview of the evidence on a specific topic.
- Meta-Analysis: St… Read full answer
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