How do you approach the design and implementation of matched case-control studies?

Sample interview questions: How do you approach the design and implementation of matched case-control studies?

Sample answer:

Approach to Designing and Implementing Matched Case-Control Studies:

1. Define Study Objectives and Hypotheses:

• Clearly state the research question and hypotheses to be tested.
• Specify the exposure(s) and outcome(s) of interest.

2. Identify Matching Criteria:

• Determine appropriate matching criteria that control for potential confounding factors.
• Consider factors such as age, sex, race/ethnicity, socioeconomic status, and geographic location.

3. Select Cases and Controls:

• Define the eligibility criteria for cases (individuals with the outcome of interest) and controls (individuals without the outcome).
• Use random sampling or other methods to select a representative sample.

4. Perform Matching:

• Use statistical methods (e.g., propensity score matching) or manual techniques to match cases to controls based on the predetermined criteria.
• Aim for a 1:1 or 1:n ratio of cases to controls.

5. Collect Data:

• Develop a standardized data collection protocol for both cases and controls.
• Collect information on exposure history,… Read full answer

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