Sample interview questions: Can you explain the concept of cell metabolism and its relevance in disease research?
Sample answer:
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Cell metabolism: Complex set of chemical reactions that occur within cells to maintain homeostasis, generate energy, and produce essential biomolecules.
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Relevance in disease research:
- Metabolic reprogramming: Cancer cells exhibit altered metabolism, characterized by increased glucose uptake and fermentation, even in the presence of oxygen (Warburg effect). Understanding these metabolic changes can aid in developing targeted therapies.
- Mitochondrial dysfunction: Many diseases, such as Parkinson’s and Alzheimer’s, are associated with mitochondrial dysfunction, leading to impaired energy production and increased oxidative stress. Studying mitochondrial metabolism can provide insights into disease mechanisms and potential treatments.
- Metabolic disorders: Inherited metabolic disorders, like diabetes, involve defects in metabolism, resulting in abnormal levels of metabolites. Studying these disorders can uncover the role of specific metabolic pathways in maintaining health and identify potential therapeutic interventions.
- Infectious diseases:… Read full answer
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