Sample interview questions: Can you describe your experience in conducting genetic research studies on rare neuromuscular disorders?
Sample answer:
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Experience in Rare Neuromuscular Disorders:
- Led a team of researchers in conducting a comprehensive genetic study on a rare neuromuscular disorder, Charcot-Marie-Tooth disease (CMT), affecting the peripheral nervous system.
- Collaborated with clinicians and geneticists to identify candidate genes responsible for the disease.
- Performed detailed molecular analyses, including whole-exome sequencing, linkage analysis, and Sanger sequencing, to identify disease-causing mutations.
- Identified novel mutations in several genes associated with CMT, expanding the genetic landscape of the disorder.
- Findings were published in a peer-reviewed journal, contributing to the understanding of CMT’s genetic basis and providing potential targets for therapeutic interventions.
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Expertise in Genetic Research Techniques:
- Proficient in various genetic research techniques, including DNA extraction, PCR amplification, Sanger sequencing, and next-generation sequencing (NGS) platforms.
- Experience in data analysis using bioinformatics tools and statistical methods to identify genetic variants associated with disease.
- Stay up-to-date with advancements in genetic technologies and methodologies to ensure the use of cutting-edge approaches in research.
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Clinical Collaboration and Patient Engagement:
- Collaborated closely with clinicians and patients to understand the clinical manifestations, disease progression, and genetic heterogeneity of rare neuromuscular disorders.
- Conducted detailed clinical evaluations, collected patient samples, and obtained informed consent for genetic studies.
- Engaged with patient advocacy groups to disseminate research findings and provide support to affected individuals and families.
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Publication and Presentation of Research Findings: