Sample interview questions: Describe your experience in using CRISPR/Cas9-based perturbation screens for identifying novel therapeutic targets in cancer.
Sample answer:
- Expertise in CRISPR/Cas9-based perturbation screens:
Demonstrate proficiency in designing and executing CRISPR/Cas9-based perturbation screens to identify novel therapeutic targets in cancer. Highlight your experience in selecting appropriate cell lines, designing guide RNA libraries, optimizing CRISPR/Cas9 delivery methods, and validating the results of the screens.
- Understanding of cancer biology and therapeutic strategies:
Discuss your knowledge of the molecular mechanisms underlying cancer development and progression, as well as the current therapeutic strategies for treating cancer. Explain how CRISPR/Cas9-based perturbation screens can be used to identify novel targets that are relevant to cancer biology and can be exploited for therapeutic purposes.
- Data analysis and interpretation:
Emphasize your skills in analyzing and interpreting the results of CRISPR/Cas9-based perturbation screens. Describe your experience in using bioinformatics tools and statistical methods to analyze the data, identify potential therapeutic targe… Read full answer
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