Sample interview questions: How do you approach the issue of incidental findings in genetic testing and research studies?
Sample answer:
Approach to Incidental Findings in Genetic Testing and Research Studies
1. Establish Clear Policies and Procedures:
* Develop ethical and legal guidelines for the handling of incidental findings.
* Determine which variants to report or withhold based on clinical significance and guidelines.
2. Patient Consent and Informed Decision-Making:
* Fully inform patients and research participants about the potential for incidental findings.
* Obtain informed consent regarding the reporting and follow-up of these findings.
* Provide clear and understandable information about the implications, risks, and benefits.
3. Clinical Evaluation and Interpretation:
* Assess the clinical significance of incidental findings using databases, expert knowledge, and patient history.
* Consult with relevant specialists (e.g., medical geneticists, oncologists) to provide a comprehensive interpretation.
4. Cascade Screening and Family Implications:
* Consider the potential impact on family members of reporting incidental findings with implications for inherited diseases.
* Offer appropriate screening and counseling to affected fam… Read full answer
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