Sample interview questions: How do you ensure the appropriate blinding and randomization processes in medical research studies?
Sample answer:
- Use a randomization service:
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Employ a centralized, independent randomization service to assign participants to treatment groups. This ensures that the allocation is truly random and not influenced by any biases.
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Conceal treatment allocation:
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Use sealed envelopes, opaque containers, or a computer-generated randomization schedule to conceal treatment allocation from researchers, participants, and study staff until after enrollment and baseline data collection.
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Implement blinding:
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Implement blinding to minimize bias and ensure that the study results are not influenced by the knowledge of treatment allocation.
- Single-blinding: Participants are unaware of their treatment assignment, but researchers are aware.
- Double-blinding: Neither participants nor researchers are aware of the treatment assignment.
- Triple-blinding: Participants, researchers, and data analysts are all unaware of the treatment assignment.
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Maintain blinding throughout the study:
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Provide participants with identical-looking placebos or treatments, use identical packaging … Read full answer
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