Sample interview questions: How do you evaluate the potential risks and benefits of a new drug before moving to clinical trials?
Sample answer:
Preclinical Evaluation of Drug Safety and Efficacy
In vitro studies:
- Cell-based assays: Assess drug effects on cell growth, viability, and function.
- Biochemical assays: Measure drug binding affinity, enzyme inhibition, and receptor modulation.
- High-throughput screening: Evaluate multiple drug candidates simultaneously for desired properties.
In vivo studies (animal models):
- Pharmacokinetic studies: Determine drug absorption, distribution, metabolism, and excretion.
- Toxicology studies: Evaluate potential adverse effects on organs, tissues, and overall health.
- Efficacy studies: Assess drug activity against disease models, including dose-response relationships and duration of action.
- Safety pharmacology studies: Evaluate potential effects on cardiovascular, respiratory, and other physiological systems.
Integration and analysis:
- Data analysis: Quantify and interpret result… Read full answer
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