Sample interview questions: Can you describe your approach to assessing and managing patients with neurologic complications of hematological or oncological disorders such as paraneoplastic syndromes?
Sample answer:
Approach to Assessing and Managing Patients with Neurologic Complications of Hematologic or Oncological Disorders
Assessment
- Comprehensive History and Physical Exam:
- Detailed account of presenting symptoms, including onset, duration, progression, and associated factors
- Neurologic examination to evaluate cognitive function, cranial nerve function, motor and sensory deficits, and reflexes
- Laboratory Tests:
- Complete blood count, electrolytes, liver function tests, renal function tests
- Tumor markers (e.g., CEA, AFP, CA-125)
- Paraneoplastic antibody panels
- Imaging Studies:
- MRI or CT scan of brain and spine
- Positron emission tomography (PET) or single-photon emission computed tomography (SPECT)
Management
- Targeted Therapy for Underlying Malignancy:
- Chemotherapy, radiation therapy, or targeted therapies to eliminate or reduce the underlying cancer
- Symptomatic Management:
- Seizure Prophylaxis: Anticonvulsants, such as levetiracetam or valproic acid
- Pain Control: Opioid analgesics, nonsteroidal anti-inflammatory drugs (NSAIDs)
- Neuroprotective Therapies: Steroids, immunosuppressive drugs (e.g., cyclophosphamide)
- Rehabilitation:… Read full answer
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